‌P u b l i c a t i o n

 * Corresponding author

2023-2024
87. Won J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I*Lee HH* (2024), "Cryo-EM structure of the heteromeric TRPC1/C4 channel", Nat. Struct. Mol. Biol. Oct. 30
85. Yun Yaejin, Jeong H, Laboute T, Martemyanov KA*Lee HH* (2024), "Cryo-EM structure of human class C orphan GPCR GPR179 involved in visual processing", Nat. Commun. 15(1): 8299
84. Kim SM*, Kang SH, Lee J, Heo Y, Poloniataki EG, Kang J, Yoon HJ, Kong SY, Yun Y, Kim H, Ryu JLee HH*, Kim YH* (2024), "Identifying a key spot for electron mediator-interaction to tailor CO dehydrogenase's affinity", Nat. Commun. 15(1): 2732.
83. Park J, Heo Y, Jeon BW, Jung M, Kim YH*Lee HH*, Roh SH* (2024), "Structure of recombinant formate dehydrogenase from Methylobacterium extorquens (MeFDH1)", Sci. Rep. 14(1):3819.
82. Jeon BW, Phan UT, Heo Y, Lee HH, Rye J*, Kim YH* (2024), "​Enzymatic conversion of CO2 to formate: The potential of tungsten-containing formate dehydrogenase in flow reactor system", J. CO2 Util  82(9):102754.
81. Yoon HJ, Lee Y, Kim SH, Kim E, Lee HH*, Jang S* (2023), "Exploring sterol transportation behavior of the Niemann-Pick C1-like 1 protein with V55L mutation: Sterol-NPC1L1 N-terminal binding energy estimation via molecular dynamics simulations", Int. J. Model. Simul. https://doi.org/10.1080/ 02286203.2023.2265543 
80. Cho Y, Nam Y, Lee HH, Chang R* (2023), "Inhibition mechanism of testis-expressed gene 14 (TEX14) in cytokinetic abscission: Well-tempered metadynamics simulation studies", J. Chem. Phys. 159(1):015102.
79. Yun Y, Yoon HJ, Jeong Y, Choi Y, Jang S, Chung KY*Lee HH* (2023), "GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin", Proc. NatI. Acad. Sci. USA 120(28): e2301934120.
78. Kim J, Won J, Chung DKLee HH* (2023), "FRET analysis of the temperature-induced structural changes in human TRPV3", Sci. Rep. 13: 10108.
77. Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I*Lee HH* (2023), "Molecular architecture of the Gαi-bound TRPC5 ion channel", Nat. Commun. 14(1): 2550.
Commentary written by Michael Zhu in Cell Calcium [click]
76. Lee SN, Cho HJ, Jeong H, Ryu BH, Lee HJ, Kim M, Yoo J, Woo JS*Lee HH* (2023), "Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel", Nat. Commun. 14(1):1347.
2021-2022
75. Kim SM, Lee J, Kang SH, Heo Y, Hanh JS, Lee HH*, Kim YH* (2022), "O2-tolerant CO dehydrogenase via tunnel redesign for the removal of CO from industrial flue gas", Nat. Catal. 5: 807-817.
highlighted by Nature "Research Highlights" [click], cover art [click]
74. Yoon HJ, Lee Y, Jeong J, Jang S*Lee HH*, Kim GS* (2022), "Binding free energy of several sterols to the N-terminal domain of Niemann-Pick C1-like 1 protein due to mutation: Molecular dynamics study", J. Chin. Chem. Soc. 70(3):539-546.
73. Choi Y, Luo Y, Lee S, Jin H, Yoon HJ, Hahn Y, Bae J*Lee HH*​ (2022), "FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations ", Nucleic Acids Res. 50(15):8929-8946.
71. Choi Y, Park JS, Kim J, Min K, Mahasenan K, Kim C, Yoon HJ, Lim S, Cheon DH, Lee Y, Ryu S, Mobashery S*, Kim BM*Lee HH* (2022), "Structure-based inhibitor design for reshaping bacterial morphology", Commun. Biol. 5(1):395.
70. Ohn J, Been KW, Kim JY, Kim EJ, Park T, Yoon HJ, Ji JS, Okada-Iwabu M, Iwabu M, Yamauchi T, Kim YK, Seok C, Kwon O, Kim KH, Lee HH*, Chung JH* (2021), "Discovery of a transdermally deliverable pentapeptide for activating AdipoR1 to promote hair growth", EMBO Mol Med. e13790
69. Cho B, Choi J, Kim R, Yun JN, Choi Y, Lee HH, Koh J* (2021), "Thermodynamic models for assembly of intrinsically disordered protein hubs with multiple interaction partners", J. Am. Chem. Soc.  143(32):12509-12523.
68. Kim DG, Lee KY, Lee SJ, Cheon SH, Choi Y, Lee HH, Ahn HC, Lee BJ* (2021), "Structural and functional studies of SAV1707 from Staphylococcus aureus elucidate its distinct metal-dependent activity and a crucial residue for catalysis", Acta Crystallogr. D Struct. Biol.  77(Pt 5):587-598.
67. Won J, Choi Y, Yun Y, Lee HH* (2021), "Biochemical Characterization of the Num1-Mdm36 Complex at the Mitochondria-Plasma Membrane Contact Site", Mol Cells 44(4):207-213.
66. Yun Y, Ji J, Lee HH* (2021), "Dissecting the structural features of β-arrestins as multifunctional proteins", Biochim. Biophys. Acta 1869(4):140603.
64. Chong SE, Oh JH, Min K, Park S, Choi S, Ahn JH, Chun D, Lee HH, Yu J, Lee Y (2021), "Intracellular delivery of immunoglobulin G at nanomolar concentrations with domain Z-fused multimeric α-helical cell penetrating peptides", J. Control. Release 330:161-172.
63. Kim DG, Cho S, Lee KY, Cheon SH, Yoon HJ, Lee JY, Kim D, Shin KS, Koh CH, Koo JS, Choi Y, Yoon HJ, Ko H, Jang S, Lee HHOh YK, Jeong YS, Chung SJ, Baek M, Jung KY, Lim HJ, Kim HS, Park SJ, Lee JY, Lee SJ*, Lee BJ* (2021), "Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity", Cell. Mol. Life Sci. 78(1):207-225.
2019-2020
62. Cho H, Choi Y, Min K, Son JB, Park H, Lee HH, Kim S (2020), "Over-activation of a nonessential bacterial protease DegP as an antibiotic strategy", Commun. Biol. 3(1):547
61. Min K, Yoon HJ, Park JY, Baidya M, Dwivedi H, Maharana J, Chung KY*, Shukla AK*Lee HH*(2020), "Crystal structure of β-arrestin 2 in complex with CXCR7 phosphopeptide", Structure 28(9):1014-1023.
60. Heo Y, Yoon HJ, Ko H, Jang S, Lee HH* (2020), "Crystal structures of Uso1 membrane tether reveal an alternative conformation in the globular head domain", Sci. Rep. 10(1):9544
59. Lee B, Jin H, Luo Y, Choi Y, Choi EH, Jin H, Kim KB, Seo SB, Kim YH, Lee HH*, Kim KP*, Lee K*, Bae J*, (2020), "FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku", Nat. Commun. 11:2010 (*Co-corresponding)
58. Min K, An DR, Yoon HJ, Rana N, Park JS, Kim J, Lee M, Hesek D, Ryu S, Kim BM, Mobashery S*, Suh SW*Lee HH*, (2020), "Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni", Nat. Commun. 11(1):458 (*Co-corresponding)
57. Kim KR, Kim KA, Park JS, Jang JY, Choi Y, Lee HH, Lee DC, Park KC, Yeom YI, Kim HJ*, Han BW* (2020), "Structural and biophysical analyses of human N-Myc Downstream-Regulated Gene 3 (NDRG3) protein", Biomolecules  10(1): E90
56. Park D, Yoon HJ, Lee KY, Park SJ, Cheon SH, Lee HH, Lee SJ, Lee BJ* (2020), "Crystal structure of proteolyzed VapBC and DNA-bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca2+-dependent riboonuclease", FASEB J. 34(2):3051-3068
55. Been K, Yoon HJ, Jeon ST, Lee HH*, (2019), "Structural characterization of a putative diguanylate cyclase conserved in hyperthermophiles", Biochem. Biophys. Res. Commun. 518(1):114-119.
54. Cho HJ, Yoon H, Lee HH*, (2019), "Phosphatidylserine-induced dissociation of the heterodimeric PstB2p/Pbi1p complex in yeast phosphatidylserine trafficking system", Biochem. Biophys. Res. Commun. 517(2):285-290
2017-2018
53. Choi Y, Kim J, Yoon HJ, Jin KS, Ryu S, Lee HH*, (2018), "Structural insights into the FtsQ/FtsB/FtsL complex, a key component of the divisome", Sci. Rep. 8(1):18061
52. Min K, Yoon HJ, Jo Inseong, Ha NC, Jin KS, Kim JS, and Lee HH* (2018), " Insights into the apo-structure of Cpf1 protein from Francisella novicida", Biochem. Biophys. Res. Commun. 498(4);775-781
51. Min K, Yoon HJ, Matsuura A, Kim YH, and Lee HH* (2018), "Structural basis for recognition of L-lysine, L-ornithine, and L-2,4-diamino butyric acid by lysine cyclodeaminase ", Mol Cells 41(4); doi: 10.14348/molcells.2018.2313
49. Kim HJ, Yoo W, Jin KS, Ryu S and Lee HH* (2017), "The role of the FliD C-terminal domain in pentamer formation and interaction with FliT", Sci. Rep. 7(1):4418; doi: 10.1038/s41598-017-02664-6
2015-2016
48. Min K and Lee HH* (2016), "Molecular aspects of CEP55 during cytokinesis and tumorigenesis", Biodesign 4(4): 89-97
47. Choi H, Min K, Mikami B, Yoon H-J, Lee HH* (2016), "Structural and biochemical studies reveal a putative FtsZ recognition site on the Z-ring stabilizer ZapD", Mol Cells 39(11): 814-820
46. Yoo W, Yoon H, Seok Y-J, Lee C-R, Lee HH and Ryu S* (2016), "Fine-tuning of amino sugar homeostasis by EIIANtr in Salmonella Typhimurium", Sci. Rep. (6)33055; doi: 10.1038/srep33055.
45. Yoon H-J, Kim HJ, Mikami B, Yu YG and Lee HH* (2016), "Crystal structure of a putative oligopeptide-binding periplasmic protein from a hyperthermophile", Extremophiles d20(5):723-731
44. Kim HJ, Kim H, chang R, Yu YG and Lee HH* (2016), "Biochemical and molecular modeling studies of the interaction between human CEP55 and TEX14", Bull. Korean Chem. SOC. 37(6):847-854
43. Kim M, Kim HJ, Son SH, Yoon H-J, Lim Y, Lee JW, Seok Y-J, Jin KS, Yu YG, Kim SK, Ryu S* and Lee HH* (2016), "Non-canonical DNA binding mode of repressor and its disassembly by antirepressor", Proc. NatI. Acad. SciUSA 113(18):E2480-2488
42. Kim HJ, Yoon J, Matsuura A, Na JH, Lee WK, Kim H, Choi JW, Park JE, Park SJ, Kim K, Chang R, Lee BI, Yu YG, Shin YK, Jeong C, Rhee K and Lee HH* (2015), "Structural and biochemical insights into the role of TEX14 in forming the stable intercellular bridges of germ cells", Proc. NatI. Acad. SciUSA 112(40):12372-12377
41. Choi H, Kim HJ, Matsuura A, Mikami B, Yoon HJ and Lee HH* (2015), " Structural and functional studies on a metallo-β-lactamase unveil a new type of structurally encoded Ni-containing heterodinuclear site", Acta Crystallogr D Biol Crystallogr. D71:2054-2065
40. Son SH and Lee HH* (2015), "Crystallization and preliminary X-ray crystallographic analysis of Z-ring associated protein (ZapD) from Escherichia coli", Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt2):194-198. 
39. Choe H, Ha JM, Joo JC, Kim H, Yoon H-J, Kim S, Son SH, Gengan RM, Jeon ST, Chang R, Jung KD, Kim YH* and Lee HH* (2015), “Structural insights into efficient CO2-reducing activity of an NAD-dependent formate dehydrogenase from Thiobacillus sp. KNK65MA”, Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt2):313-323
38. Kim S-K**, Park Y-C**, Lee HH**, Jeon ST, Min W-K, Seo J-H (2015), "Simple amino acid tags improve both expression and secretion of Candida antarctica lipase B in recombinant Escherichia coli", Biotechnol. Bioeng. 112(2):346-355. (**co-first authors)
2010-2014
37. Lee WK, Son SH, Jin BS, Na JH, Kim SY, Kim EK, Yu YG* and Lee HH* (2013), "Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140", Proc. NatI. Acad. Sci. USA 110(48):19360-19365. 
36. Matsuura A and Lee HH* (2013), "Crystal structure of GTPase-activating domain from human MgcRacGAP", Biochem. Biophys. Res. Commun. 435(3):367-372.
35. Son SH and Lee HH* (2013), "The N-terminal domain of EzrA binds to the C terminus of FtsZ to inhibit Staphylococcus aureus FtsZ polymerization“, Biochem. Biophys. Res. Commun. 433(1):108-114.
34. Han SG, Lee WK, Jin BS, Lee KI, Lee HH, and Yu YG* (2013), "Identification of Novel Irreversible Inhibitors of UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) from Haemophilus influenzae“, J. Microbiol. Biotechnol. 23(3):329-334.
33. Lee HH* and Jung ST (2013), "Overexpression, crystallization, and preliminary X-ray crystallographic analysis of β-N-acetylglucosaminidase from Thermotoga maritima by the Tm0809 gene" Acta Crystallogr F Struct Biol Commun. 2013 Feb 1;69(Pt 2):115-117. 
32. Matsuura A**, Yoon JY**, Yoon HJ**, Lee HH*, Suh SW* (2012), "Crystal structure of pyridoxal biosynthesis lyase PdxS from Pyrococcus horikoshii“, Mol. Cells 34(4):407-412. (**co-first authors)
31. Son SH, Lee DY, Kim YJ, Ko S, Cho SJ, Jung HC, Lee HH* (2012), "Cloning, expression, and polymerization assay of FtsZ protein from Staphylococcus aureus“, KJMB 40(3):274-277.
30. Lee SJ, Lee S, Lee SK, Yoon H, Lee HH, Kim KK, Lee BJ, Lee BI, and Suh SW* (2012), "Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors“, Acta Crystallogr D Biol. Crystallogr. 2012 Jul;68(Pt 7):784-793. 
29. Yoon JY, Park CR, Lee HH* and Suh SW* (2012), "Overexpression, crystallization, and preliminary X-ray crystallographic analysis of pyridoxal biosynthesis lyase PdxS from Pyrococcus horikoshii“, Acta Crystallogr F Struct Biol Cryst. Commun. 2012 Apr 1;68(Pt 4):440-442. 
28. Lee HH**, Nemecek D**, Schindler C**, Smith WJ, Ghirlando R, Steven AC, Bonifacino JS, and Hurley JH (2012), "Assembly and Architecture of the Biogenesis of Lysosome-Related Organelles Complex-1 (BLOC-1)“, J. Biol. Chem. 287(8):5882-5890. (**co-first authors)
26. Yoon HJ, Kang JY, Mikami B, Lee HH*, Suh SW* (2011), "Crystal structure of phosphopantetheine adenylyltransferase from Enterococus faecalis in the ligand-unbound state and in complex with ATP and pantetheine“, Mol. Cells 32(5):431-435.
25. Lee HH* (2011), “Overexpression, crystallization, and preliminary X-ray crystallographic analysis of shikimate dehydrogenase from Thermotoga maritima”, Acta Crystallogr F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):824-826.
24. Lee HH*, Jang JY, Yoon HJ, Kim SJ, Suh SW* (2010), “Crystal structures of two archaeal Pelotas reveal inter-domain structural plasticity”, Biochem. Biophy. Res. Commun. 399(4):600-606.
23. Lee HH*, Suh SW* (2010), “Overexpression, crystallization, and preliminary X-ray crystallographic analysis of Pseudomonas aeruginosa MnmE, a GTPase involved in tRNA modification”, Acta Crystallogr F Struct Biol Cryst Commun. 2010 Aug 1;66(Pt 8):905-908.
2002-2009
22. Lee HH**, Yoon HJ**, Kang JY, Park JH, Kim DJ, Choi KH, Lee SK, Son J, Kim HJ, Suh SW (2009), “Crystal structure of Staphylococcus aureus phosphopantetheine adenylyltransferase in complex with 3’ -phosphoadenosine 5’-phosphosulfate reveals a new ligand binding mode”, Acta Crystallogr F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt 10): 987-991. (**equally contributed)
21. Wollert T, Yang D, Ren X, Lee HH, Im YJ, Hurley JH (2009), “The ESCRT machinery at a glance”, J. Cell Sci. 122(Pt 13):2163-2166. 
20. Hurley JH, Im YJ, Lee HH, Ren X, Wollert T, Yang D (2009), “Piecing together the ESCRTs”, Biochem. Soc. Trans. 37(Pt 1):161-166. 
19. Lee HH, Elia N, Ghirlando R, Lippincott-Schwartz J, Hurley JH (2008), “Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55”, Science 322(5901):576-580. (highlighted in “This Week in Science”) 
18. Kim do J, Lee SJ, Kim HS, Kim KH, Lee HH, Yoon HJ, Suh SW (2008), “Structural basis of octanoic acid recognition by lipoate-protein ligase B”, Proteins 70(4):1620-1625. 
17. Lee HH**, Kim HS**, Kang JY, Lee BI, Ha JY, Yoon HJ, Lim SO, Jung G, Suh SW (2007), “Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface”, Proteins 69(3): 672-678. (**equally contributed)
15. Lee HH, Kim YS, Kim KH, Heo I, Kim SK, Kim O, Kim HK, Yoon JY, Kim HS, Kim DJ, Lee SJ, Yoon HJ, Kim SJ, Lee BG, Song HG, Kim VN, Park CM, Suh SW (2007), “Structural and Functional Insights into Dom34, a Key Component of No-Go mRNA Decay”, Mol. Cell 27(6):938-950. 
14. Ha JY, Kim HK, Kim DJ, Kim KH, Oh SJ, Lee HH, Yoon HJ, Song HK, Suh SW (2007), “The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding”, Nucleic Acids Res. 35(8):2671-2681.
13. Ha JY, Lee JH, Kim KH, Kim DJ, Lee HH, Kim HK, Yoon HJ, Suh SW (2007), “Crystal Structure of D-Erythronate-4-phosphate Dehydrogenase Complexed with NAD,” J. Mol. Biol. 366(4):1294-1304.
12. Kang JY, Lee HH, Kim DJ, Han SH, Kim O, Kim HS, Lee SJ, Suh SW (2006), “Overexpression, crystallization and preliminary X-ray crystallographic analysis of a putative transposase from Thermoplasma acidophilum encoded by the Ta0474 gene”, Acta Crystallogr F Struct Biol Commun. 2006 Nov 1;62(Pt 11):1147-1149. 
11. Kang JY, Lee HH, Yoon HJ, Kim HS, Suh SW (2006), “Overexpression, crystallization and preliminary X-ray crystallographic analysis of phosphopantetheine adenylyltransferase from Enterococcus faecalis”, Acta Crystallogr F Struct Biol Commun. 2006 Nov 1;62(Pt 11):1131-1133. 
10. Ha JY, Min JY, Lee SK, Kim HS, Kim DJ, Kim KH, Lee HH, Kim HK, Yoon HJ, Suh SW (2006), “Crystal structure of 2-nitropropane dioxygenase complexed with FMN and substrate: Identification of the catalytic base”, J. Biol. Chem. 281(27):18660-18667. 
9. Lee HH, Yoon JY, Kim HS, Kang JY, Kim KH, Kim DJ, Ha JY, Mikami B, Yoon HJ, Suh SW (2006), “Crystal structure of a metal ion-bound IS200 transposase”, J. Biol. Chem. 281(7):4261-4266.
8. Ha JY, Lee JH, Kim KH, Kim DJ, Lee HH, Kim HK, Yoon HJ, Suh SW (2006), “Overexpression, crystallization, and preliminary X-ray crystallographic analysis of erythronate-4-phosphate dehydrogenase from Pseudomonas aeruginosa”, Acta Crystallogr F Struct Biol Commun. 2006 Feb 1;62(Pt 2):139-141.
7. Kim DJ, Kim KH, Lee HH, Lee SJ, Ha JY, Yoon HJ, Suh SW (2005), "Crystal structure of lipoate-protein ligase A bound with the activated intermediate: Insights into interaction with lipoyl domains,” J. Biol. Chem. 280(45):38081-38089.
6. Kim KH, Ahn HJ, Kim DJ, Lee HH, Ha JY, Kim HK, Yoon HJ, Suh SW (2005), “Expression, crystallization, and preliminary X-ray crystallographic analysis of human agmatinase”, Acta Crystallogr F Struct Biol Commun. 2005 Oct 1;61(Pt 10):889-891.
5. Ahn HJ, Kim KH, Lee J, Ha JY, Lee HH, Kim DJ, Yoon HJ, Kwon AR, Suh SW (2004), “Crystal structure of agmatinase reveals structural conservation and inhibition mechanism of the ureohydrolase superfamily”, J. Biol. Chem. 279(48):50505-50513.
4. Lee HH**, Kim DJ**, Ahn HJ, Ha JY, Suh SW (2004), “Crystal structure of T-protein of the glycine cleavage system: Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia”, J. Biol. Chem. 279(48):50514-50523. (American Society for Biochemistry and Molecular biology) (**equally contributed)
3. Kim HL, Yoon HJ, Ha JY, Lee BI, Lee HH, Mikami B, Suh SW (2004), “Crystallization and preliminary X-ray crystallographic analysis of nicotinic acid mononucleotide adenylyltransferase from Pseudomonas aeruginosa”, Acta Crystallogr D Biol Crystallogr. 60(Pt 5):948-949. (International Union of Crystallography)
2. Kim HW, Han BW, Yoon HJ, Yang JK, Lee BI, Lee HH, Ahn HJ, Suh SW (2002), “Crystallization and preliminary X-ray crystallographic analysis of peptide deformylase from Pseudomonas aeruginosa”, Acta Crystallogr D Biol Crystallogr. 58(Pt 10 Pt 2):1874-1875.
1. Lee HH, Yun J, Moon J, Han BW, Lee BI, Lee JY, Suh SW (2002), “Crystallization and preliminary X-ray crystallographic analysis of enoyl-acyl carrier protein reductase from Helicobacter pylori”, Acta Crystallogr D Biol Crystallogr. 58(Pt 6 Pt 2):1071-1073.