Hyung Ho Lee

Current Research Interests
Membrane receptors and channels represent the gateway through which the cell senses and responds to its environment. Most physiologically important processes are initiated by the interaction of cell-surface receptors/channels with extracellular mediators. This recognition event is communicated across the membrane, resulting in activation of intracellular signal transduction cascades. We ask how information is transmitted across the cell membrane at the molecular level.
It is easy to agree that "Seeing is believing". The roots of our research are in the power of x-ray crystallography and cryoEM to reveal the structures of biomolecules at atomic level, leading to insights in the physical basis of protein-protein interactions. The core approach is complemented by studies in solution or on membranes by hydrodynamics, small angle x-ray scattering, fluorescence imaging, and various biophysical tools. The structural, biochemical, and biophysical experiments lead to new hypotheses about biological function and mechanism. We also try to demonstrate our new hypotheses in cells using various cell biological tools. Crystal structures of drug target proteins can also be used to discover new lead compounds by structure-based drug discovery (SBDD) method. We are interested in various drug target proteins to treat various diseases including cancer.

 

---